A Way Through the Crowd: Motility of macrophages in a dense microenvironment

Macrophages – the most versatile and multipurpose cells of the immune system – scavenge away pathogens and sick cells to protect us from diseases. We have previously mentioned how macrophages also happen to be present in almost every tissue to perform this very function. Most of the immune cells continuously circulate in the blood, but in aContinue reading “A Way Through the Crowd: Motility of macrophages in a dense microenvironment”

Toxoplasma gondii – a new cancer fighting superhero

“Life will win over death, and light will win over darkness”– Volodymyr Zelenskyy, President of Ukraine “I would not be here today if it wasn’t for you and your discovery” – said Tomas Dahl during the meeting in Stockholm. Tomas was one of the cancer patients who had the prestigious chance to share their storyContinue reading “Toxoplasma gondii – a new cancer fighting superhero”

A better method for T cell isolation is not so enigMATIC anymore

When we talk on the topic of cancer therapies, the first one that comes to my mind is adoptive T cell therapy using tumor-infiltrating lymphocytes (TILs). It has received a lot of good reviews in the last couple of years and persists as a promising tumor therapy for the future. It works on the principleContinue reading “A better method for T cell isolation is not so enigMATIC anymore”

A step towards affordable cell therapy using mRNA technology

This image was created with Biorender.com A decade ago, a novel immunotherapy ravaged two pounds of cancer cells and revolutionized the treatment of blood cancer. This immunotherapy isolated T cells from a patient and inserts a gene encoding synthetic chimeric antigen receptor (CAR) ex-vivo into T cells. These CARs contain regions to redirect T cellsContinue reading “A step towards affordable cell therapy using mRNA technology”

A Combo offer to deal with Melanoma: Latest Development with Immune Checkpoint Inhibitors

Modern Science has experienced huge breakthroughs over the last decades, one of the major ones being the discovery of immune checkpoints and their inhibitors. The checkpoint inhibitors revolutionized the stagnant field of cancer biology and were responsible for the rise of cancer immunotherapies. Immunotherapies command the immune system to destroy tumors by using antibodies againstContinue reading “A Combo offer to deal with Melanoma: Latest Development with Immune Checkpoint Inhibitors”