Bridging the “gap” between CAR and solid tumors
Picture credit: flickr.com Since first approved by the FDA in 2017, T cells with chimeric antigen receptors (CAR T) have revolutionized the treatment of blood cancers like leukemia and lymphoma. Since then, research has been focused on improving the CARs to treat a wide range of cancers including solid tumors – that have proved to…
Are CAR Tregs a reason for CAR therapy failure?
Created with Biorender.com On 12th of September 2022, Zinaida Good, a postdoctoral fellow at Stanford University, tweeted: “We found a CAR Treg subset in CD19-CAR T cells for lymphoma. We hope that this finding will put us on a path from 40% cure to 100% cure”.Only five years earlier, FDA had made historical approval for…
New Role of Macrophages Concerning Ischemic Injuries Discovered
Blood vessels, like roads, connect all parts of our body to the heart. Through those well enclosed walls, blood circulates to every crevice to deliver oxygen and nutrients vital for survival of tissues. The heart pumps blood into the aorta that branches out into arteries that in turn further branch into capillaries, together fulfilling the…