Tag: mouse model

  • Shifting Paradigms: T Cells, FlipFlops, and Reversed T Cells

    Shifting Paradigms: T Cells, FlipFlops, and Reversed T Cells

    You must have come across the fundamental concepts of T cell development during your immunology class. Briefly, in the thymus, T cells expressing both CD4 and CD8 coreceptors interact with MHC molecules on thymic epithelial cells to make lineage fate decisions. CD4+ cells interact with MHCII and are called T helper cells while CD8+ cells […]

  • The Battle of the Ts: Regulatory CD8+ T cells suppress autoimmunity associated CD4+ T cells

    The Battle of the Ts: Regulatory CD8+ T cells suppress autoimmunity associated CD4+ T cells

    “The enemy of my enemy is my friend” – Proverb Over years of evolution, our immune system successfully dealt with a variety of foreign invaders such as viruses, bacteria, fungi, and uni- and multi-cellular parasites. Starting 1900s, doctors and scientists started discovering a faulty immune system (mainly T and B cells) in patients, attacking their […]