Tag: CAR T
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Bridging the “gap” between CAR and solid tumors
Picture credit: flickr.com Since first approved by the FDA in 2017, T cells with chimeric antigen receptors (CAR T) have revolutionized the treatment of blood cancers like leukemia and lymphoma. Since then, research has been focused on improving the CARs to treat a wide range of cancers including solid tumors – that have proved to…
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Monolog 1 – No mercy for cancer
In this monolog, Jatin briefly discusses the recent study from Lai et al. about FLT3L-secreting CAR T cells that successfully elicited a polyclonal immune response in Her2 and OVA co-expressing tumor models. Check out our memes on Facebook (@antibuddies) and Twitter (@antibuddiesP). Website: Antibuddies – Science Communication & Immunology (Antibuddies.org) Join us on our monthly journal…
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Are CAR Tregs a reason for CAR therapy failure?
Created with Biorender.com On 12th of September 2022, Zinaida Good, a postdoctoral fellow at Stanford University, tweeted: “We found a CAR Treg subset in CD19-CAR T cells for lymphoma. We hope that this finding will put us on a path from 40% cure to 100% cure”.Only five years earlier, FDA had made historical approval for…
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A step towards affordable cell therapy using mRNA technology
This image was created with Biorender.com A decade ago, a novel immunotherapy ravaged two pounds of cancer cells and revolutionized the treatment of blood cancer. This immunotherapy isolated T cells from a patient and inserts a gene encoding synthetic chimeric antigen receptor (CAR) ex-vivo into T cells. These CARs contain regions to redirect T cells…
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