Tag: CAR T

  • Are CAR Tregs a reason for CAR therapy failure?

    Are CAR Tregs a reason for CAR therapy failure?

    Created with Biorender.com On 12th of September 2022, Zinaida Good, a postdoctoral fellow at Stanford University, tweeted: “We found a CAR Treg subset in CD19-CAR T cells for lymphoma. We hope that this finding will put us on a path from 40% cure to 100% cure”.Only five years earlier, FDA had made historical approval for […]

  • A step towards affordable cell therapy using mRNA technology

    A step towards affordable cell therapy using mRNA technology

    This image was created with Biorender.com A decade ago, a novel immunotherapy ravaged two pounds of cancer cells and revolutionized the treatment of blood cancer. This immunotherapy isolated T cells from a patient and inserts a gene encoding synthetic chimeric antigen receptor (CAR) ex-vivo into T cells. These CARs contain regions to redirect T cells […]