Tag: cancer

  • A Sheep in Wolf’s Clothing: Mimicking Tumor with Probiotic

    A Sheep in Wolf’s Clothing: Mimicking Tumor with Probiotic

    Created using BioRender.com Take a look in the mirror. What do you see? Given that you are reading an immunology blog, I hope your answer would be something along the line of a human being, or Homo sapiens if you want to be fancy. Now, let’s take a closer look together! At the genetic level, […]

  • Unleashing the Anti-tumor Immune Cells with Dostarlimab

    Unleashing the Anti-tumor Immune Cells with Dostarlimab

    Blocking checkpoint proteins enhance immune cell activity In healthy individuals, the immune system is intricately regulated to maintain homeostasis. Consider it as a see-saw: on the one hand, excessive immune activation in the absence of harmful pathogens may manifest as autoimmune diseases; on the other hand, inadequate immune defense creates vulnerability during infections. The immune […]

  • A Way Through the Crowd: Motility of macrophages in a dense microenvironment

    A Way Through the Crowd: Motility of macrophages in a dense microenvironment

    Macrophages – the most versatile and multipurpose cells of the immune system – scavenge away pathogens and sick cells to protect us from diseases. We have previously mentioned how macrophages also happen to be present in almost every tissue to perform this very function. Most of the immune cells continuously circulate in the blood, but in a […]

  • Toxoplasma gondii – a new cancer fighting superhero

    Toxoplasma gondii – a new cancer fighting superhero

    “Life will win over death, and light will win over darkness”– Volodymyr Zelenskyy, President of Ukraine “I would not be here today if it wasn’t for you and your discovery” – said Tomas Dahl during the meeting in Stockholm. Tomas was one of the cancer patients who had the prestigious chance to share their story […]

  • A better method for T cell isolation is not so enigMATIC anymore

    A better method for T cell isolation is not so enigMATIC anymore

    When we talk on the topic of cancer therapies, the first one that comes to my mind is adoptive T cell therapy using tumor-infiltrating lymphocytes (TILs). It has received a lot of good reviews in the last couple of years and persists as a promising tumor therapy for the future. It works on the principle […]

  • A step towards affordable cell therapy using mRNA technology

    A step towards affordable cell therapy using mRNA technology

    This image was created with Biorender.com A decade ago, a novel immunotherapy ravaged two pounds of cancer cells and revolutionized the treatment of blood cancer. This immunotherapy isolated T cells from a patient and inserts a gene encoding synthetic chimeric antigen receptor (CAR) ex-vivo into T cells. These CARs contain regions to redirect T cells […]

  • A Combo offer to deal with Melanoma: Latest Development with Immune Checkpoint Inhibitors

    A Combo offer to deal with Melanoma: Latest Development with Immune Checkpoint Inhibitors

    Modern Science has experienced huge breakthroughs over the last decades, one of the major ones being the discovery of immune checkpoints and their inhibitors. The checkpoint inhibitors revolutionized the stagnant field of cancer biology and were responsible for the rise of cancer immunotherapies. Immunotherapies command the immune system to destroy tumors by using antibodies against […]

  • Immunology: Bigger than it seems

    Immunology: Bigger than it seems

    A World Immunology Day 2021 special post Immunology is the study of immune cells that are the body’s defense against everything that is foreign and can damage our body. Immune systems have been around for millions of years, protecting all sorts of organisms including plants and bacteria from harm. The field of Immunology has seen […]

  • Memory T cells persist after neoantigen vaccine in melanoma patients

    Memory T cells persist after neoantigen vaccine in melanoma patients

    Vaccines are not oblivious, especially in 2021, but when we say ‘vaccine’ we usually refer to something that can prevent an infection. Have you ever heard of therapeutic vaccines? One revolutionary therapeutic vaccine for melanoma, a new personal neoantigen vaccine called NeoVax, was developed by Ott et al. and its early clinical outcome was published […]