Category: Blog

  • Unleashing the Anti-tumor Immune Cells with Dostarlimab

    Unleashing the Anti-tumor Immune Cells with Dostarlimab

    Blocking checkpoint proteins enhance immune cell activity In healthy individuals, the immune system is intricately regulated to maintain homeostasis. Consider it as a see-saw: on the one hand, excessive immune activation in the absence of harmful pathogens may manifest as autoimmune diseases; on the other hand, inadequate immune defense creates vulnerability during infections. The immune […]

  • Can our adipose tissue handle an infection?

    Can our adipose tissue handle an infection?

    A little fat won’t kill you – well, this may be a lie, but could I interest you in a story where a little fat could ‘save’ you after infection? This discovery definitely got my motor running. Could the adipocyte (a fat cell) act as an immune cell and clear the infection? Unfortunately, Caputa et […]

  • Shifting Paradigms: T Cells, FlipFlops, and Reversed T Cells

    Shifting Paradigms: T Cells, FlipFlops, and Reversed T Cells

    You must have come across the fundamental concepts of T cell development during your immunology class. Briefly, in the thymus, T cells expressing both CD4 and CD8 coreceptors interact with MHC molecules on thymic epithelial cells to make lineage fate decisions. CD4+ cells interact with MHCII and are called T helper cells while CD8+ cells […]

  • The Battle of the Ts: Regulatory CD8+ T cells suppress autoimmunity associated CD4+ T cells

    The Battle of the Ts: Regulatory CD8+ T cells suppress autoimmunity associated CD4+ T cells

    “The enemy of my enemy is my friend” – Proverb Over years of evolution, our immune system successfully dealt with a variety of foreign invaders such as viruses, bacteria, fungi, and uni- and multi-cellular parasites. Starting 1900s, doctors and scientists started discovering a faulty immune system (mainly T and B cells) in patients, attacking their […]

  • A Camel to the Rescue: Nanobodies against SARS-CoV-2

    A Camel to the Rescue: Nanobodies against SARS-CoV-2

    Created with BioRender.com Amid the COVID-19 pandemic, antibodies have been under the spotlight as potential therapeutics. Antibodies patrol the body and bind to their specific target region, known as an epitope, on an antigen. In humans, antibodies consist of 2 heavy chains and 2 light chains held together by disulfide bonds (see graphical abstract). However, as […]

  • Neutrophils help organs heal

    Neutrophils help organs heal

    Most of us had our knees bruised when we were kids: riding a bicycle, climbing the trees, playing soccer… and it was so fascinating to look at the tissue healing process following that – the development of fibrotic tissue, skin remodeling, and so on… Only much later in our life, did we come to know […]

  • A Way Through the Crowd: Motility of macrophages in a dense microenvironment

    A Way Through the Crowd: Motility of macrophages in a dense microenvironment

    Macrophages – the most versatile and multipurpose cells of the immune system – scavenge away pathogens and sick cells to protect us from diseases. We have previously mentioned how macrophages also happen to be present in almost every tissue to perform this very function. Most of the immune cells continuously circulate in the blood, but in a […]

  • Toxoplasma gondii – a new cancer fighting superhero

    Toxoplasma gondii – a new cancer fighting superhero

    “Life will win over death, and light will win over darkness”– Volodymyr Zelenskyy, President of Ukraine “I would not be here today if it wasn’t for you and your discovery” – said Tomas Dahl during the meeting in Stockholm. Tomas was one of the cancer patients who had the prestigious chance to share their story […]

  • An Unexpected Linkage: The Gut-Skin Axis

    An Unexpected Linkage: The Gut-Skin Axis

    Created with BioRender.com In the public discussion of microbes, there is often a negative connotation attached to microbes such as bacteria, viruses, fungi, and parasites due to the presence of pathogenic individuals in each category. However, microbes are not synonymous with pathogens. For instance, some gut bacteria are well-acknowledged for their importance in the nutrient […]

  • New Role for Ductal Cells in Type 1 Diabetes

    New Role for Ductal Cells in Type 1 Diabetes

    Despite owning the same genetic material, our cells carry out highly specialized functions and vary from each other in many phenotypic aspects. Interestingly, when in troubled times (i.e., under stressful conditions) certain cells change their characteristic protein expression and turn into something completely unexpected, to help us survive. Fasolino and group shed light on such […]