Buddisodes

60-min discussions about immunology research with our hosts. From Buddisode 15 onwards, we started inviting authors to talk about their work.

We continue We sit down with Dr. Jorge-Dominguez Andres (Ph.D.) from Radboud University to discuss trained immunity and its transgenerational inheritance in mice.
Article of discussion: Transmission of trained immunity and heterologous resistance to infections across generations | Nature Immunology
We continue our discussion with Dr. Adewunmi Adelaja (M.D., Ph.D.), from the University of California Los Angeles, about NFkB signaling and how signals to different stimuli are relayed inside macrophages.
Article of discussion: Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses – ScienceDirect
We sit down with Dr. Adewunmi Adelaja (M.D., Ph.D.) from the University of California Los Angeles to discuss NFkB signaling and how signals to different stimuli are relayed inside macrophages.
Article of discussion: Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses – ScienceDirect
we sit down with Dr. Yosuke Kumamoto from Rutgers new jersey medical school to discuss the role of a specific subset of DCs that retain lymphocytes in the SLOs to scan the repertoire post-immunization.
Article of discussion: https://www.science.org/doi/10.1126/sciimmunol.abg0336
In the 2nd part of the Origin of Eukaryotes series, Dara and Jatin sit down with Dr. Dylan G Ryan from University of Cambridge (formerly at Trinity College Dublin) to discuss his 2020 perspective article about the role of TCA cycle in Eukaryogenesis.
Article of discussion: TCA cycle signalling and the evolution of eukaryotes (nih.gov)
In the 1st part of the Origin of Eukaryotes series, Dara and Jatin sit down with Dr. Dylan G Ryan from University of Cambridge (formerly at Trinity College Dublin) to discuss his 2020 perspective article about the role of TCA cycle in Eukaryogenesis.
Article of discussion: TCA cycle signalling and the evolution of eukaryotes (nih.gov)
In the second part of the two-part series. Eugenio, Natalie, & Jatin continue their discussion with Xiaolei Su, Qian Xiao, and Ceara McAtee about phase separation in Immune signaling.
Article of discussion: Phase separation in immune signalling | Nature Reviews Immunology
This is the first part of the two-part series. In this Buddisode, Eugenio, Natalie, & Jatin sit down with Xiaolei Su, Qian Xiao, and Ceara McAtee from Yale cancer center at Yale university to discuss their latest review article published in Nature Immunology Reviews in July of 2021.
Article of discussion: Phase separation in immune signalling | Nature Reviews Immunology
In this Buddisode, Dara, Eugenio, Natalie, & Jatin sit down with Daniel from Gretchen Diehl’s lab at Memorial Sloan Kettering Cancer Center, NY. The discussion entails their 2021 paper about the development of bacteria-specific T cells in the thymus of young mice and all the implications surrounding this discovery.
Article of discussion: Thymic development of gut-microbiota-specific T cells | Nature
In this Buddisode, Dara & Jatin sit down with Adam Fike from Ziaur Rahman’s lab at Penn State University. The discussion entails their 2020 publication that teased apart the contribution of Type I and Type II interferons in TLR7-mediated systemic autoimmunity.
Article of discussion: Type II but Not Type I IFN Signaling Is Indispensable for TLR7-Promoted Development of Autoreactive B Cells and Systemic Autoimmunity | The Journal of Immunology (jimmunol.org)
In this Buddisode, Eugenio, Natalie, and Jatin sit down with Dr. Wei-le Wang who is a posdoc in the lab of Dr. Marco Colonna lab at Washington University, St. Louis. The discussion entails Wei-le’s recent publication that finds a unique niche around the CNS where new immune cells are formed.
Article of discussion: Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders | Science (sciencemag.org)
In this episode, Eugenio, Natalie, and Jatin sit down with Drs. Rafael Flores and Matthew Yousefzadeh to discuss their recent research that aims to dissect the role of the immune system in systemic aging.
Article of discussion: An aged immune system drives senescence and ageing of solid organs | Nature
In this episode, Eugenio, Tanu, and Jatin sit down with Dr. Eric Song from Yale School of Medicine to discuss his recent publication that associates neuroinvasive properties with SARS CoV2.
Article of discussion: Neuroinvasion of SARS-CoV-2 in human and mouse brain | Journal of Experimental Medicine | Rockefeller University Press (rupress.org)
In this episode, Eugenio, Dara, and Jatin sit down with Dr. Shiv Pillai from Harvard medical school to discuss about his lab’s recent publication about the state of germinal centers in severe COVID19
Article of discussion: The loss of Bcl-6 expressing T follicular helper cells and the absence of germinal centers in COVID-19 (nih.gov)
In this episode, Eugenio, Natalie, and Jatin sit down with Dr. Evgeny Kiner from Immunai and discuss about his earlier publication about a continuum of T helper phenotypes seen in vivo.
Article of discussion: Gut CD4 + T cell phenotypes are a continuum molded by microbes, not by T H archetypes | Nature Immunology
In this episode, Eugenio, Natalie, and Jatin sit down with Dr. Deepak Rao from Harvard Medical School and discuss about his lab’s 2019 publication about peripheral helper T cells that could potentially be providing help to B cells outside the follicles.
Article of discussion: PD-1hiCXCR5– T peripheral helper cells promote B cell responses in lupus via MAF and IL-21 (nih.gov)
In this episode, Eugenio, Natalie, and Jatin sit down with Dr. Claudia Jakubzick from Dartmouth University. They discus Claudia’s 2018 publication that elucidated the role of natural IgM in the recognition of neoantigens in absence of PAMPs.
Article of discussion: Immune Surveillance by Natural IgM Is Required for Early Neoantigen Recognition and Initiation of Adaptive Immunity (nih.gov)
In this episode, we sit down with Dr. Ken Cadwell from New York University to talk about his recent article about decoy exosomes secreted by epithelial cells to defend against bacterial toxins.
Article of discussion: Decoy exosomes provide protection against bacterial toxins | Nature
In this episode, we sit down with Dr. Yi-ru Yu, a post doctoral researcher at the department of oncology (University of Lausanne, Switzerland) to talk about his recent article studying mitochondrial dynamics in the exhaustion of tumor infiltrating lymphocytes (TILs).
Article of discussion: Disturbed mitochondrial dynamics in CD8 + TILs reinforce T cell exhaustion | Nature Immunology
In this episode, Eugenio, Jatin, and Natalie discuss about the requirement of 2nd signal in B cells.
Article of discussion: https://www.nature.com/articles/s41590-020-0765-7
In this episode, Eugenio, Jatin, and Natalie discuss about the a the role of STING’s Interferon-independent pathways in T cells and macrophages. Source: https://www.sciencedirect.com/science/article/abs/pii/S1074761320302648?via%3Dihub
In this episode, Eugenio, Jatin, and Natalie discuss about the a the role T cells in anxiety in murine models.
Source: https://www.cell.com/cell/fulltext/S0092-8674(19)31117-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867419311171%3Fshowall%3Dtrue
In this episode, Eugenio, Jatin, and Natalie discuss about the a unique mode of non-genetic multigenerational inheritance in colonic Tregs.
Source: https://www.sciencedirect.com/science/article/abs/pii/S0092867420304931
In this episode, Antia and Jatin discuss about the unique profiles of T cells that produce and/or respond to Interleukin 2. What determines whether a T cell will produce IL-2 or not? Find out in this episode.
Sources: https://pubmed.ncbi.nlm.nih.gov/30213884/
In this episode, Antia and Jatin continue to discuss about the recent developments in cancer nano medicine.
Sources: https://www.nature.com/articles/s41577-019-0269-6
In this episode, Antia and Jatin discuss about the recent developments in cancer nano medicine.
Source: https://www.nature.com/articles/s41577-019-0269-6
In this buddisode, Tanu and Jatin discuss about HLA’s association with body odor, mate selection, and procreation in humans.
Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519788/
In this buddisode, Tanu and Jatin discuss about the WHO mega trial, the breakthrough french study, and discuss some research articles investigating the efficacy of hydroxychloroquine and NHC.
Sources: https://stm.sciencemag.org/node/213730.full https://www.nature.com/articles/s41421-020-0156-0
In this buddisode, Antia and Jatin discuss about a recent study from 2016 that highlights the different metabolic requirements of T and B cells under homeostatic conditions. Also, Antia cannot pronounce the word “extrinsic”.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936487/
In this buddisode, Antia and Jatin discuss about a recent study that shows improved secondary immune responses during dietary restriction. Also, Antia cannot pronounce glucocorticoids.Source:
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818271/
In this buddisode, Tanu and Jatin discuss about a SARS CoV2 patient case study who recovered from non-severe COVID19.
Source: https://www.nature.com/articles/s41591-020-0819-2
In this buddisode, Tanu, a PhD student in virology, tells us about the SARS coronavirus that is related to the CoVID 19 currently in discussion worldwide. We then talk about an article looking at T cell responses to the SARS coronavirus.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683413/
In this buddisode, Dr. Winni Hui talks about exosomes derived from salmonella-infected macrophages.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29158431/
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