Author: yguo0826

  • Unleashing the Anti-tumor Immune Cells with Dostarlimab

    Unleashing the Anti-tumor Immune Cells with Dostarlimab

    Blocking checkpoint proteins enhance immune cell activity In healthy individuals, the immune system is intricately regulated to maintain homeostasis. Consider it as a see-saw: on the one hand, excessive immune activation in the absence of harmful pathogens may manifest as autoimmune diseases; on the other hand, inadequate immune defense creates vulnerability during infections. The immune […]

  • A Camel to the Rescue: Nanobodies against SARS-CoV-2

    A Camel to the Rescue: Nanobodies against SARS-CoV-2

    Created with BioRender.com Amid the COVID-19 pandemic, antibodies have been under the spotlight as potential therapeutics. Antibodies patrol the body and bind to their specific target region, known as an epitope, on an antigen. In humans, antibodies consist of 2 heavy chains and 2 light chains held together by disulfide bonds (see graphical abstract). However, as […]

  • An Unexpected Linkage: The Gut-Skin Axis

    An Unexpected Linkage: The Gut-Skin Axis

    Created with BioRender.com In the public discussion of microbes, there is often a negative connotation attached to microbes such as bacteria, viruses, fungi, and parasites due to the presence of pathogenic individuals in each category. However, microbes are not synonymous with pathogens. For instance, some gut bacteria are well-acknowledged for their importance in the nutrient […]

  • Slowing Down Inflamm-Aging with Diet

    Slowing Down Inflamm-Aging with Diet

    Source: istock What if I tell you that you can greatly improve your immune system by just cutting your calories by 40%?  If you are as skeptical as I, your cursor would be on its way to the “close tab” button after reading that first sentence. In my very personal and non-scientific opinion, a 40% […]

  • A step towards affordable cell therapy using mRNA technology

    A step towards affordable cell therapy using mRNA technology

    This image was created with Biorender.com A decade ago, a novel immunotherapy ravaged two pounds of cancer cells and revolutionized the treatment of blood cancer. This immunotherapy isolated T cells from a patient and inserts a gene encoding synthetic chimeric antigen receptor (CAR) ex-vivo into T cells. These CARs contain regions to redirect T cells […]