Author: wordybiologist

  • On the Cutting Edge: The OMICS Generation

    On the Cutting Edge: The OMICS Generation

    The last two decades have seen rapid development in almost every aspect of human life, and the field of biomedicine is no different. By the time the Human Genome Project concluded, the field of genomics had already observed a steady drop in the cost of sequencing. In years that followed, the technology developed rapidly, and […]

  • Shifting Paradigms: T Cells, FlipFlops, and Reversed T Cells

    Shifting Paradigms: T Cells, FlipFlops, and Reversed T Cells

    You must have come across the fundamental concepts of T cell development during your immunology class. Briefly, in the thymus, T cells expressing both CD4 and CD8 coreceptors interact with MHC molecules on thymic epithelial cells to make lineage fate decisions. CD4+ cells interact with MHCII and are called T helper cells while CD8+ cells […]

  • A Way Through the Crowd: Motility of macrophages in a dense microenvironment

    A Way Through the Crowd: Motility of macrophages in a dense microenvironment

    Macrophages – the most versatile and multipurpose cells of the immune system – scavenge away pathogens and sick cells to protect us from diseases. We have previously mentioned how macrophages also happen to be present in almost every tissue to perform this very function. Most of the immune cells continuously circulate in the blood, but in a […]

  • New Role for Ductal Cells in Type 1 Diabetes

    New Role for Ductal Cells in Type 1 Diabetes

    Despite owning the same genetic material, our cells carry out highly specialized functions and vary from each other in many phenotypic aspects. Interestingly, when in troubled times (i.e., under stressful conditions) certain cells change their characteristic protein expression and turn into something completely unexpected, to help us survive. Fasolino and group shed light on such […]

  • A Song of Marrow and Microbes

    A Song of Marrow and Microbes

    Stem cells! Iron! Macrophages! Red blood cells! Butyrate! Gut microbiota! No, we are not just blurting out random terms (stick with us till the end to read the full story). These keywords summarize a study by Zhang and colleagues that was published in Cell Stem Cell earlier this month. However, summarizing the work in a single […]

  • The Spoils of Epstein-Barr Virus and Its Role in Multiple Sclerosis

    The Spoils of Epstein-Barr Virus and Its Role in Multiple Sclerosis

    Picture source: iStock, Health Central 2022 is off to a great start for Science as Harvard researchers published a study that potentially solves a longstanding question: Can viral infections cause Multiple Sclerosis (MS)? According to their findings, the answer is yes, we can confidently say that Epstein-Barr Virus (EBV), a long-term suspect for causing this […]

  • Goodnight, Sleep tight, don’t take your immunity light!

    Goodnight, Sleep tight, don’t take your immunity light!

    “Early to bed and early to rise makes one healthy, wealthy and wise.” Day and night have existed for as long as the earth and sun- since before the beginning of life forms. So, it is not surprising that a large number of organisms, including all eukaryotes, have evolved considering day and night cycles. These […]

  • The COVID-19 Research Rundown

    The COVID-19 Research Rundown

    The grim COVID-19 pandemic shows no sign of stopping, with the Delta variant bringing new waves of infections across the world. Thankfully, the vaccination efforts are running on full throttle leading to rarer cases of adverse effects, at least amongst the vaccinated crowds (1). And now that the Pfizer mRNA vaccine has been approved by […]

  • New Role of Macrophages Concerning Ischemic Injuries Discovered

    New Role of Macrophages Concerning Ischemic Injuries Discovered

    Blood vessels, like roads, connect all parts of our body to the heart. Through those well enclosed walls, blood circulates to every crevice to deliver oxygen and nutrients vital for survival of tissues. The heart pumps blood into the aorta that branches out into arteries that in turn further branch into capillaries, together fulfilling the […]

  • A Combo offer to deal with Melanoma: Latest Development with Immune Checkpoint Inhibitors

    A Combo offer to deal with Melanoma: Latest Development with Immune Checkpoint Inhibitors

    Modern Science has experienced huge breakthroughs over the last decades, one of the major ones being the discovery of immune checkpoints and their inhibitors. The checkpoint inhibitors revolutionized the stagnant field of cancer biology and were responsible for the rise of cancer immunotherapies. Immunotherapies command the immune system to destroy tumors by using antibodies against […]