Author: tarasbaranovskyi
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Are CAR Tregs a reason for CAR therapy failure?
Created with Biorender.com On 12th of September 2022, Zinaida Good, a postdoctoral fellow at Stanford University, tweeted: “We found a CAR Treg subset in CD19-CAR T cells for lymphoma. We hope that this finding will put us on a path from 40% cure to 100% cure”.Only five years earlier, FDA had made historical approval for…
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Novel role of immune cells in hair growth
We normally lose from 50 to 100 hairs every day. Whether we notice it or not, lost hair is replaced with newly growing ones all the time. So far, we know of several factors that can disrupt this balance and lead to significant hair loss; including heredity, hormonal changes, infectious agents, medications (for instance drugs…
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Mutation in innate immune receptor can cause lupus
You stash your drugs in a lupus textbook (Dr. Foreman) It’s never lupus (Dr. House) From House MD But today it is! I assume that Hugh Laurie’s character would have loved the recent work of Brown and colleagues published in Nature. Dr House had diagnosed lupus only once within eight seasons of the series, and…
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The Battle of the Ts: Regulatory CD8+ T cells suppress autoimmunity associated CD4+ T cells
“The enemy of my enemy is my friend” – Proverb Over years of evolution, our immune system successfully dealt with a variety of foreign invaders such as viruses, bacteria, fungi, and uni- and multi-cellular parasites. Starting 1900s, doctors and scientists started discovering a faulty immune system (mainly T and B cells) in patients, attacking their…
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Toxoplasma gondii – a new cancer fighting superhero
“Life will win over death, and light will win over darkness”– Volodymyr Zelenskyy, President of Ukraine “I would not be here today if it wasn’t for you and your discovery” – said Tomas Dahl during the meeting in Stockholm. Tomas was one of the cancer patients who had the prestigious chance to share their story…
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Host microbiota affects the brain’s innate immune system
“I’m Gonna Make Him an Offer He Can’t Refuse.” -Don Vito Corleone It could be a quote from a dialogue between the host microbiota and the host immune system… Let’s figure it out step by step. Did you know that beneficial microorganisms live in and on our bodies? An adult human body consists of approximately…
Antibuddies 